Effects of Certain Antiallergic Drugs on Experimental Conjunctivitis in Guinea Pigs
スポンサーリンク
概要
- 論文の詳細を見る
Effects of certain antiallergic drugs on experimental conjunctivitis were studied with guinea pigs. Chlorpheniramine, ketotifen and levocabastine were effective in inhibiting histamine-and antigen-induced conjunctivitis in guinea pigs. By contrast, amlexanox was only effective in inhibiting antigen-induced conjunctivitis. Topical application of antigen released 46.5±3.8% of histamine from the conjunctiva in sensitized guinea pigs. Both levocabastine and amlexanox were effective in inhibiting conjunctival histamine release induced by antigen application. Lacrimal histamine contents were also increased after antigen challenge. The increase in the histamine content of tears was inhibited by pretreatment with levocabastine and amlexanox, but no significant effect was observed with chlorpheniramine and ketotifen. From these findings, it is concluded that certain antiallergic drugs, but not amlexanox, exhibited potent inhibition on experimental conjunctivitis in guinea pigs. In addition, it has been established that measurement of histamine in the conjunctiva and tears as well as observation of conjunctivitis syndromes are useful for evaluating the effectiveness of antiallergic drugs on various kinds of allergic conjunctivitis in clinical situations.
- 公益社団法人日本薬学会の論文
- 1995-11-15
著者
-
中村 哲
Department of Physics, Tohoku University
-
亀井 千晃
岡山大学薬学部薬物学講座
-
中村 哲
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
-
出石 啓治
岡山大学薬学部薬物学教室
-
亀井 千晃
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
-
出石 啓治
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
-
亀井 千晃
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
関連論文
- 125 ペパーミントに含まれる抗アレルギー成分の探索と有効性
- Status Report of Neutral Kaon photo-production study using Neutral Kaon Spectrometer 2 (NKS2) at LNS-Tohoku(I. Nuclear Physics)
- Double Pion Photoproduction on Deuteron(I. Nuclear Physics)
- Study of Strangeness Photo-production in the Threshold Region at LNS-Tohoku(I. Nuclear Physics)
- Photoproduction of Neutral Kaons on Liquid Deuterium Target(I. Nuclear Physics)
- ヒスタミンH_1受容体欠損マウスを用いたオロパタジンの薬効評価
- レボカバスチンとペミロラスト併用による作用増強についての検討
- ラットのアレルギー性結膜炎に対する塩酸レボカバスチンの効果
- 126 皮膚反応におけるヒスタミンH_3受容体の関与
- 109 能動感作ヒスタミンH1受容体欠損マウスを用いたアレルギー性鼻炎の解析
- 452 アレルギー性鼻炎におけるヒスタミンH1受容体の役割
- ラットの空間認知記憶における脳内ヒスタミンの関与
- 274 デキストラン硫酸誘発潰瘍性大腸炎モデルにおけるマスト細胞の関与
- 203 ヒスタミン誘発引っ掻き行動におけるヒスタミンH1およびH2受容体の関与について
- 放射状迷路課題を用いた空間認知学習に対するヒスタミン神経系の関与
- 420 Compound 48/80による皮膚反応におけるヒスタミンの関与
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- Development of a Liquid Deuterium Target System for the Neutral Kaon Spectrometer(I. Nuclear Physics)
- A Quasi-free Photo-production of Neutral Kaons on ^C in the Threshold Region(I. Nuclear Physics)
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- Radiation Hardness Test of a Silicon Strip Detector by Electron Beam Irradiation(I. Nuclear Physics)
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- Energy Calibration of the STB-Tagger(I. Nuclear Physics)
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- Photoproduction of Neutral Kaons on Carbon in the Threshold Region(I. Nuclear Physics)
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- 各種薬物誘発健忘に対するイチョウ葉エキスの効果
- イチョウ葉エキス成分EGb761の記憶障害改善作用
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- Comparison of the ^Ca (e, e'p) Cross Section at Low Momentum Transfer Region with Relativistic Calculations(I. Nuclear Physics)
- ラットの睡眠覚醒サイクルに対する第2世代抗ヒスタミン薬の影響
- 161 モルモット好酸球からのeosinophil peroxidase(EPO)遊離に対するβ_2-agonistの脱感作機序について
- 323 ヘアレスマウスを用いたアトピー性皮膚炎モデルの作製
- Cephem系抗生物質の痙攣誘発作用について
- ヒスタミン研究-最近の話題-
- ラットの睡眠覚醒サイクルに対するクロロゲン酸およびその代謝物の効果
- ラットの睡眠障害モデルの作製および各種短時間型催眠薬の効果
- ラット扁桃核キンドリング発作に対する各種ヒスタミンH3受容体拮抗薬の効果
- ラット扁桃核キンドリング発作におけるヒスタミン神経系の関与
- H1拮抗薬の中枢抑制作用に対するヒスタミン, アセチルコリンおよびセロトニン受容体の関与
- Effects of Certain Antiallergic Drugs on Experimental Conjunctivitis in Guinea Pigs
- Effect of Histamine on Memory Retrieval in Old Rats
- 490 抗アレルギー薬のactive avoidance responseに及ぼす影響について
- 中枢ヒスタミン神経系と扁桃核キンドリング
- モルモットの実験的アレルギー性結膜炎に対する Substance P の関与
- モルモットの実験的アレルギー性結膜炎に対する Substance P の関与
- 62 モルモットの実験的結膜炎の作成および抗アレルギー薬の効果に関する検討
- 111 肥満細胞のホスファチジルイノシトール代謝およびヒスタミン遊離に及ぼすcAMPの影響
- 442 肥満細胞からのヒスタミン遊離におけるピロテインキナーゼCの関与