フェノチアジン誘導体の製剤的研究(第4報) : プロペリシアジンおよびそのスルホオキシドの光分解と安定化

概要

論文の詳細を見る
Photodecomposition of propericiazine (I) and its sulfoxide (II) was carried out by irradiation of fluorescent light (twelve 20 W tubes of cool white light, ca. 5000 luces) on their acid solution sealed in ampules, under various conditions. I is stable to light in nitrogen atmosphere but is photooxidized in thepresence of air, forming II in the main and partly 7-oxo-2-phenothiazinecarbonitrile (III), which was found to be responsible for the red coloration of the solution. II was found to be photoreduced to I under various conditions. Quantitative studies were made on the photodecomposition of I and II in buffer solution, by colorimetric determination using a palladium chloride reagent. At the same time, effect of various additives on the photodecomposition was also examined. It was thereby found that a certain equilibrium is reached between I and II during the process of photodecomposition and this equilibrium is dependent on pH of the solution and content of oxygen in the ampules. Rate of photooxidation increased with increasing amount of oxygen and lowering of pH, while the rate of photoreduction decreased with increasing pH and amount of oxygen. Photooxidation is not affected by the addition of maleic or picolinic acid but photoreduction is inhibited by these additives.
社団法人日本薬学会の論文
1966-06-25