漢方製剤の薬剤学的品質評価に関する研究(第4報)麻黄中のアルカロイドの漢方湯液調製時の挙動について

概要

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Titrimetric determination of alkaloids in commercial ephedra herb was made by three extraction methods, using ether (JP IX), MeOH, or hot water, and the highest content was obtained by hot water extraction. High-speed liquid chromatographic determination was also made on the same samples, using two column materials, Bondapak C_<18> and μPorasil, with MeOH : NH_4OH (400 : 8) as the developing solvent, and a good correlation was found between the values obtained by titrimetry and those by liquid chromatography. The recovery of ephedrine or alkaloids from the decoction of ephedra herb added with glycyrrhiza radix, cinnamon cortex, armeniac seeds, or their mixture (Maoo-to without ephedra herb) ranged between 55 and 83%. The pH of these decoctions were below 7.0,where ephedrine and methylephedrine did not distill out with steam during decoction. It was assumed that the decrease in alkaloid recovery in Maoo-to originated in adsorption of these alkaloids on crude drug materials in the decoction solution.
公益社団法人日本薬学会の論文
1978-07-25