安定性予測に関する研究(第2報)ディジタルコンピュータによる予測

概要

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A method for the prediction of shelf life of pharmaceutica1 preparations under noniso thermal shelf condition has been developed using a digital computer. When the temperature function is T=f(t), k=k_0exp E/R×[1/f(0)-1/f(t)] is derived, and by substitution of this equation into the reaction rate equation, the drug remaining undecomposed is calculated by numerical integration. The calculated results were in good agreement with the experimental values when four pharmaceutical preparations were stored in three different places for 1 year and the temperature changes were expressed as Fourier series.
公益社団法人日本薬学会の論文
1975-11-25