安定性予測に関する研究(第1報)アナログコンピュータによる予測

概要

論文の詳細を見る
A method for the prediction of shelf life of pharmaceutical preparations under nonisothermal shelf condition has been developed using an analog computer. When the temperature fuction is 1/T=f(t), dk/dt=-E/R×kf' (t) is derived, and the drug remaining undecomposed is calculated using this equation and the reaction rate equation. Shelf life of the preparations can be predicted when the reciprocal of shelf temperature approximates to the sine curve or Fourier series. The calculated results were in good agreement with the experimental values when four pharmaceutical preparations were stored in three different places for 1 year and the reciprocals of this temperature change were expressed as Fourier series.
公益社団法人日本薬学会の論文
1975-11-25