固形医薬品の溶解(第1報)単分散結晶の溶解

概要

論文の詳細を見る
The application of numerical analysis is suitable for the estimation of rate constant of dissolution and the simulation of dissolution under nonsink conditions. The dissolution rate constants of various particle sizes of methyl-, ethyl-, propyl-, butylparaben were calculated by the numerical analysis, and it was clarified that the product of dissolution rate constant by particle size is nearly equal for all experiments and that the dissolution rate constants do not change under both sink and nonsink conditions. The effects of solubility, nonsink condition, crystal size and crystal shape on dissolution rate were simulated.
公益社団法人日本薬学会の論文
1982-03-25