ラット大動脈Lipidosisの早期発症

概要

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Studies were made on the experimental conditions for the rapid dietary induction of aortic lipidosis in rats and results obtained showed that the strain of the animal as well as the type of fat in diet was a very important factor for the early development of the lesion. Gross aortic lipidosis was produced regularly after 4 weeks in Sprague-Dawley rats by feeding a semi-synthetic diet containing 3% cholesterol, 1% cholic acid, 0.3% thiouracil, 21% hydrogenated fat, 30% lactose, and 40% casein. Densitometric determinations of gross aorta stained with Sudan made quantitative assessment of the severity and extent of the lesions possible. In all these experiments no significant correlation exsisted between the degree of vasular lipidosis and the serum of liver lipid levels. Histopathological examinations of the aorta revealed some accumulation of lipid-filled foam cells in the subendothelial space, disintegration of the internal elastic lamella, and lipid deposits in smooth muscle cells in the media. Corticosteroid hormones significantly suppressed the development of short-term aortic lipidosis, while they elevated serum cholesterol levels compared with that of control.
公益社団法人日本薬学会の論文
1974-07-25