ラットにおける食餌による急性高コレステロール血症

概要

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Studies were made on the rapid dietary induction of hypercholestereolemia in rats, with a view to employing experimental conditions thereof in our first screening of orally active hypocholesterolemic agents. The experimental results confirmed that the sex differences had no influence, but the strain, age, body weight of the animals, and diet had a great effect on elevation of serum cholesterol levels. Marked hypercholesterolemia was induced when such strains of rats as showing a high sensitivity to exogenous cholesterol were fed a high fat diet containing 2% cholesterol and 1% cholic acid for a period of 3 days. The hypocholesterolemic activity of natural and synthetic substances was determined in the 3-day oral assay. The most active compound was diethylstilbestrol, followed by L-thyroxine, eritadenine, and β-estradiol. Nicotinic acid, clofibrate, and fradiomycin proved active when given in large doses.
公益社団法人日本薬学会の論文
1972-07-25