アズレン誘導体に関する研究 : 家兔口腔粘膜からの吸収, 排泄について(in Vivo)

概要

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In vivo Experiments were carried out on the oral mucosal absorption and excretion of azulene derivatives in rabbits. Azulene derivatives used were water-soluble guaiazulene (sodium 1,4-dimethyl-7-isopropylazulene-3-sulfonate) and guaiazulene, in comparison with naphthalenes as a control. Water-soluble guaiazulene transited rapidly into blood after its administration and was excreted into urine but guaiazulene was hardly absorbed and its blood level was extremely low. Further examinations were therefore made on test compounds with respect to the presence or absence of electric charge, binding ability with blood proteins, effect of solvent at the time of administration, and effect of a liquid layer on oral mucosa. It was thereby found that the absorption of azulene derivatives from rabbit oral mucosa occurred when there was a polar substituent in these compounds.
公益社団法人日本薬学会の論文
1974-10-25