ジルチアゼムに関する薬物相互作用の研究(第2報)プロプラノロールのBioavailabilityに及ぼすジルチアゼムの併用投与の影響

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Drug interaction between diltiazem and propranolol was studied in dog and human from the standpoint of bioavailability. It was found that oral co-administration of diltiazem enhanced the bioavailability of propranolol in dog without affecting the biological half-lives. This effect was proportional to the doses of diltiazem from 5 to 60 mg per head and seemed to be comparable to the effect of food. Similar but lesser effect was also observed when diltiazem was co-administered by non-oral routes. Inter-individual uniformity of plasma propranolol levels as well as dose proportionality of the peak level and area under the curve were improved by the co-administration of diltiazem. In healthy subjects and patients, there was a tendency toward elevation in plasma propranolol levels by the combined administration of diltiazem as in the case of dogs, but the mean blood pressure and heart rates were not different significantly as compared to that of diltiazem or propranolol alone. No change in the plasma diltiazem levels was confirmed on the co-adiministration with propranolol in any species.
公益社団法人日本薬学会の論文
1983-04-25