Hydrocortisoneによるマウス腹腔マクロファージのZymosan付着および貪食の抑制

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The relationships between adherence of zymosan and phagocytosis by macrophages with the release of 6-keto-prostaglandin F_<1α> (6KF_<1α>) and thromboxane B_2 (TXB_2), the stable endometabolites PGI_2 and TXA_2 respectively, from macrophages were investigated with mouse peritoneal macrophages. Zymosan-induced release of 6KF_<1α> and TXB_2 was inhibited by indomethacin, an inhibitor of cyclo-oxygenase, and by hydrocortisone, an inducer of the inhibitor of phospholipase A_2. Although release of 6KF_<1α> and TXB_2 was significantly enhanced by the interaction of attachment of zymosan particles to cell membranes, the interaction was inhibited by hydrocortisone, not by indomethacin. From these results it is suggested that phospholipase A_2 participates in the interaction of zymosan particles with cell membranes for the release of 6KF_<1α> and TXB_2.
社団法人日本薬学会の論文
1982-07-25