Adjuvant Effect of Photobacterium phosphoreum PJ-1 on Humoral Immune Response of ddY Mice to Sheep Erythrocytes
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概要
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The effects of Photobacterium phosphoreum PJ-1 from a luminous marine fish on the immune response of ddY mice to sheep erythrocytes (SRBC) were examined. Simultaneous intravenous injection of P.phosphoreum PJ-1 and SRBC markedly enhanced the formations of the splenic direct and indirect plaque-forming cells (PFC) against SRBC on day 7 after the immunization. The anti-SRBC hemolysin titers in sera were also markedly enhanced by the simultaneous administration of P.phosphoreum PJ-1 and SRBC, and this effect of the organism on hemolytic response to SRBC was still observed on day 34 after the immunization. The injection of P.phosphoreum PJ-1 one day after and 14 days before the immunization also significantly enhanced the splenic direct and indirect PFC responses to SRBC. In addition, the administration of P. phosphoreum PJ-1 one day before the immunization significantly enhanced only the splenic direct PFC response to SRBC. These results show that the marine bacterium P. phosphoreum PJ-1 is available as an adjuvant for studies on the immune responses to SRBC in ddY mice.
- 1981-09-25
著者
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桑江 豊保
Department of Physiological Chemistry, Faculty of PharmaceuticalSciences, Josai University
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倉田 宗司
Department of Physiological Chemistry, Faculty of PharmaceuticalSciences, Josai University
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桑江 豊保
城西大学薬学部
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倉田 宗司
Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences:josai University Sakado
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深沢 茂樹
Department of Biochemistry, Faculty of Science
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倉田 宗司
Department Of Physiological Chemistry Faculty Of Pharmaceuticalsciences Josai University
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深沢 茂樹
Department Of Chemistry Faculty Of Science:josai University Sakado
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Kurata M
Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Josai University
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