カルシウム動員レセプターの活性化機構-膜リン脂質を介する情報変換

概要

論文の詳細を見る
Physiological signals such as peptide hormones and neurotransmitters are recognized on the surface of their target cell membranes and they bind to specific receptors on it. These interactions then initiate biochemical alterations in membranes which in turn allow stimulated cells to exert their various specific functions. It is now well documented that one of the earliest and crucial membrane changes in the stimulus-response compling is the rapid turnover of phosphoinositides. Compelling experimental evidence indicates that the calcium ion mobilizing receptors affect intracellular calcium levels via hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP_2) into inositol trisphosphate (IP_3) and diacylglycerol (DG), which serves as intracellular second messengers. The former acts as an effective releaser of calcium ion from intracellular stores and the latter messenger is a potent activator of protein kinase C. Recently, it is known that guanine nucleotide-binding protein (s) is involved in the coupling of calcium ion mobilizing receptors of PIP_2 hydrolysis and calcium ion mobilization. This review will focus on the signal transduction mechanism in the receptor activation of human platelets.
社団法人日本薬学会の論文
1987-12-25