(RS)-7-(2-Aminomethylmorpholino)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acidの結晶水の挙動
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概要
- 論文の詳細を見る
Physicochemical characteristics of crystalline water of (RS)-7-(2-amino-methylmorpholino)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid were studied by thermal analyses and powder X-ray diffractmetry. The dihydrate of the compound was stable under ambient or humidified conditions. The dihydrate converted to a monohydrate on drying under mild conditions. The mono-and dihydrates transformed into α-type anhydrate at 110℃. These three kinds of crystals were convertible each other under appropriate conditions. At 165℃, the hydrates and the α-anhydrate converted to β-type anhydrate. The compressed effects on the crystalline waters were also discussed for the dihydrate by kinetic analyses.
- 社団法人日本薬学会の論文
- 1992-10-25
著者
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小川 建志
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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小川 建志
吉富製薬株式会社中央研究所
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荒木 和彦
吉富製薬株式会社中央研究所
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今村 香織
吉富製薬株式会社中央研究所
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大石 直寛
吉富製薬株式会社中央研究所
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石田 靖彦
吉富製薬株式会社中央研究所
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