Gastric Acidity-Dependent Bioavailability of Commercial Sustained Release Preparations of Indomethacin, Evaluated by Gastric Acidity-Controlled Beagle Dogs
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概要
- 論文の詳細を見る
The relationship between gastric acidity and the bioavailability of two kinds of sustained-release indomethacin (IM) formulations was investigated in gastric acidity-controlled beagle dogs, and compared with that of rapid-release IM formulations.All test dosage forms were more rapidly dissolved in simulated intestinal fluid than in simulated gastric fluid.Gastric acidity did not affect the bioavailability of IM from the rapid-release formulation. However, the bioavailability of IM from the two kinds of sustained-release formulations were markedly influenced by gastric acidity. The rates of IM bioavailability from both of the sustained-release formulations were faster under low acidity conditions than under high acidity conditions (p<0.01). In addition, T_<max> and mean residence time (MRT) were approximately the same for the rapid-release and sustained-release formulations under low acidity conditions.These results suggest that the IM sustained-release formulations showed a rapid-release profile under low acidity conditions.
- 公益社団法人日本薬学会の論文
- 1990-11-25
著者
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小川 建志
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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山田 一磨呂
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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川田 美和子
Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.
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合田 智子
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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塩月 宜子
Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd.,
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塩月 宜子
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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川田 美和子
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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- Gastric Acidity-Dependent Bioavailability of Commercial Sustained Release Preparations of Indomethacin, Evaluated by Gastric Acidity-Controlled Beagle Dogs
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