Powder Coating Mixture of a Novel Anxiolytic, Y-23684 : Dissolution Characteristics and Bioavailability
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概要
- 論文の詳細を見る
A powder coating mixture was investigated with a view toward improving the dissolution property of the anxiolytic 2-(4-chlorophenyl)-5,6-dihydro-[1]benzo-thiepino-[5,4-c]-pyridazin-3(2H)-one 7-oxide (1), which was barely water soluble. The powder coating mixture in various ratios of 1 and cornstarch was prepared in an automated mortar. Among these mixtures, at the cptimum ratio of 1 and cornstarch (2 : 1,67% drug content), the powder coating mixture gave a maximized effect for solubilizing 1 on the bases of stability and solubility. Conventional granules were made from the 67% powder coating mixture. The granules showed an excellent absorption profile in beagle dogs. The mechanism of the solubilizing effect resulting from a phatmaceutical process was also discussed.
- 公益社団法人日本薬学会の論文
- 1992-04-25
著者
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小川 建志
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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山田 一磨呂
Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.
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鮫元 博文
Pharmaceutical Development Analytical & Pharmaceutical Research Laboratories Yoshitomi Pharmaceu
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矢田 智子
Pharmaceutical Development Analytical & Pharmaceutical Research Laboratories Yoshitomi Pharmaceu
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山田 一磨呂
Pharmaceutical Development Analytical & Pharmaceutical Research Laboratories, Yoshitomi Pharmaceutic
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小川 建志
Pharmaceutical Development Analytical & Pharmaceutical Research Laboratories, Yoshitomi Pharmaceutic
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