Gastric pH Profile and Its Control in Fasting Beagle Dogs

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概要

• 論文の詳細を見る

• The gastric pH of fasting beagle dogs was measured by using an ion-selective field effect transistor pH sensor. In addition, a novel procedure to control the gastric pH in fasting beagle dogs was investigated Inter-and intra-day variations in the gastric pH of the dogs were observed. The gastric pH of the dogs could be controlled by a single intravenous administration of omeprazole, an H^+, K^+-adenosine triphosphatase (ATPase) inhibitor (1mg/0.25ml/kg). The pH in the stomach was 6.6±0.2(mean±S.D., n=6) at 1h after the omeprazole treatment, and this level of pH was maintained for a period of at least 3h. Beagle dogs in which the gastric pH has been controlled by omeprazole are considered to be useful as an animal model to be used for the pharmaceutical evaluation of drugs in subjects with a low acidity level.

• 社団法人日本薬学会の論文
• 1989-09-25

著者

• 小川 建志

  Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.

• 山田 一磨呂

  Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.

• 水田 博彰

  吉富製薬株式会社中央研究所

• 水田 博彰

  Research Laboratories, Yoshitomi Pharmeceutical Industries, Ltd.,

• 水田 博彰

  Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.

• 合田 智子

  Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd.,

• 山田 一麿呂

  Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd.,

• 芳賀 慶一朗

  Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd.,

• 芳賀 慶一朗

  Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.

• 合田 智子

  Research Laboratories Yoshitomi Pharmaceutical Industries Ltd.

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