化粧品用赤色201号の副色素の分析とその変異原性に関する研究

概要

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Five subsidiary dyes of Lithol Rubine B (C.I. 15850) were synthesized to clear the chemical structures of mutagenic impurities in the commercial cosmetic Lithol Rubine B. Their analyses by HPLC were investigated and the mutagenic activities examined by Ames test by using Salmonella typhimurium TA 98 and TA 100. The subsidiary dyes and Lithol Rubine B were completely separated by the gradient HPLC analysis by using an Inertsil ODS column and acetonitrile-water-formic acid system as a mobile phase. The subsidiary dyes showed no mutagenic activities to S. typhimurium with or without S9mix. These results suggest that the mutagenic activities may not be due to the subsidiary dyes but to some reaction intermediates in the synthetic process of Lithol Rubine B.
公益社団法人日本薬学会の論文
1990-04-28