生化学的データからの高齢者の骨代謝状態の評価

概要

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In order to estimate metabolic bone condition, urinary pyridinoline (Pyr), deoxypyridinoline (D-Pyr) and urinary calcium, as well as serum Pyr and osteocalcin were tested as biochemical markers for bone metabolism in elderly in-patients who do not have metabolic bone disease, but rather, cerebrovascular disease. All the patients recruited in this study were divided into two groups of each sex, according to their mobility : the "able to walk without assistance"(W group) or the "could not walk independently"(NW group). Serum Pyr, urinary Pyr and D-Pyr of the NW group were significantly higher than those of the W group in the females, and a similar trend was observed among the male subjects. The levels of serum osteocalcin, one of the bone formation markers tested, showed no statistical difference between W and NW group in either sex. Patients 70-79 years old were selected from the above determined groups, and their serum Pyr, and urinary Pyr, D-Pyr and calcium were periodically determined and compared. In both sexes of the NW group, these markers were higher and increased over time than those of the W group. These results suggest that bone resorption in the NW group in both sexes accelerates over time and their fracture risk, therefore, increases, even if they have no metabolic bone disease.
社団法人日本薬学会の論文
1998-06-30