Studies on the Metabolic Fate of α-Bromocinnamaldehyde (an Anti-Fungal Agent) in Rat

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After single oral administration of ^<14>C-α-bromocinnamaldehyde (^<14>C-α-BCA) to rats, a peak of radioactivity in blood was observed at 3 h and a high level was observed until 12 h. Among the organs and tissues, high radioactivity was found in liver and kidney until 96 h after dosing. About 27 and 70% of dosed radioactivity were excreted in feces and urine within 48 h, respectively. As urinary metabolites, hippuric acid, α-bromocinnamoylglycine, α-bromocinnamic acid and α-bromocinnamyl alcohol were identified. Daily oral dosing for 7 d did not reveal any accumulation in any particular organ, compared with the result after single dosing. When radioactive bile from rats administered ^<14>C-α-BCA was injected into the duodenum of another rat, about 33% and 42% of the radioactivity were excreted within 48 h in bile and urine, respectively, via enterohepatic circulation.
社団法人日本薬学会の論文
1988-08-30