繊維染色キャリヤ2-クロルエチルベンゾエートの生体内運命

概要

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^<14>C-2-Chloroethyl benzoate (^<14>C-CEB) was given to animal to investigate its fate in the body, and the following results were observed ; The absorption rate of ^<14>C-CEB was so fast that a radioactivity in blood was observed 15 min after a single oral administration. Relatively higher distributions of radioactivity were noted in the liver and kidney comparing with other many organs. Almost all radioactivity of dose was excreted only in the urine 12 h after the administration, and its accumulation was not recognized in any region of the body. The rate of distribution to tissues after a cutaneous application was also fast, and the radioactivity was rapidly excreted as well as in the case of oral dosing. The amount of radioactivity transferred into the bile was only 0.8% of the dose 24 h after an intravenous injection. The urinary metabolite corresponding to 99.3% of the radioactivity in the rat urine was identified to be hippuric acid by thin-layer chromatography (TLC) and isotope dilution method. Additionally, p-hydroxybenzoic acid was also detected in the hydrolyzed rat urine.
公益社団法人日本薬学会の論文
1986-08-31