有害性金属の生体膜生合成に及ぼす影響 : カドミウムのホスホリパーゼA_2活性に及ぼす影響について

概要

論文の詳細を見る
Kinetic studies on the inhibition of phospholipase A_2 (from Agkistrodon halys blomhoffii) activity with cadmium ion demonstrated that cadmium ion inhibits the enzymic activity competitively with respect to calcium ion and phosphatidylcholine. The Km value was 6.3×10^<-3>M for phosphatidylcholine and the Ki value of cadmium ion was 1.4×10^<-4>M, while, for the calcium ion, the K_m value was 2.8×10^<-4>M and K_1 value of cadmium ion was 1.4×10^<-4>M. Cadmium-metallothionein isolated from the liver of cadmium-injected mouse did not show any effect on the phospholipase A_2 activity and this fact suggests the protective effect of metallothionein against toxic effect of cadmium on lipid metabolism in living cells.
公益社団法人日本薬学会の論文
1978-10-31