ラットにおけるPolychlorinated Dibenzo-p-dioxinsの糞中排泄に対する食物繊維の効果

概要

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The effect of dietary fibers on the liver distribution and fecal excretion of polychlorinated dibenzo-p-dioxins (PCDDs) congeners in the causal rice-bran oil of Yusho was examined in male rats. The fibers used were rice-bran fiber, spinach fiber, burdock fiber, cabbage fiber, soybean fiber, Japanese-radish (root) fiber, carrot fiber, corn fiber, Japanese-radish (leaves) fiber, Chinese cabbage fiber, azuki bean fiber and barley fiber. The animals were administered 4 g of each diet containing 0.5 ml of the rice-bran oil and kept on the same fiber for another 5 d. The oil was contaminated with 1,2,3,7,8-P_5CDD (6.86 ng/ml), 1,2,3,6,7,8-H_6CDD (31.4 ng/ml), 1,2,3,7,8,9-H_6CDD (22.4 ng/ml) and 1,2,3,4,6,7,8-H_7CDD (121.7 ng/ml). The fecal excretion of 1,2,3,7,8-P_5CDD in the group fed with rice-bran and spinach fibers were promoted 3.3 and 3.1 times, respectively, than that in the group fed with a non-fiber diet. The excretion of 1,2,3,6,7,8-H_6CDD, 1,2,3,7,8,9-H_6CDD and 1,2,3,4,6,7,8-H_7CDD were 2.1,1.9 and 1.6 times higher, respectively, in the groups fed with rice-bran and spinach fibers than that in the group fed with the non-fiber diet. The present results suggest that the dietary fibers are useful agents for the treatment of patients exposed to the lipophilic contaminants.
公益社団法人日本薬学会の論文
1997-02-28