Cytochrome P450 Expression in Rat Ocular Tissues and Its Induction by Phenobarbital
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概要
- 論文の詳細を見る
Composition and inducibility of cytochrome P450 (CYP) in ocular tissues were investigated using reverse transcription-polymerase chain reaction (RT-PCR) and immunoblot techniques. Composition of ocular CYPs is more restricted than that of hepatic forms. High levels of CYP2B1/2 and reduced levels of CYP2C11 expression were detected in rat ocular tissues. Phenobarbital induced CYP2B1/2 expression in the lens but not in the rest of the eye, whereas CYP2C11 induction was observed in both regions. In addition, CYP2B1/2 proteins were found to be prominent in the retina. Our data indicate eye-specific regulation of CYP expression.
- 公益社団法人日本薬学会の論文
- 2002-08-01
著者
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KOBAYASHI Shizuko
Kyoritsu College of Pharmacy
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TAMURA Hiro-omi
Kyoritsu College of Pharacy
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Takehana Makoto
Kyoritsu College Of Pharmacy
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Tanaka Hiroyuki
Kyoritsu College of Pharmacy
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Hirayama Ikuko
Kyoritsu College of Pharmacy
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