Sulfoconjugation of Bisphenol A in a Human Neuroblastoma Cell Line, NB-1
スポンサーリンク
概要
- 論文の詳細を見る
Bisphenol A (BPA) is a common environmental endocrine disruptor and BPA sulfate has been demonstrated as one of metabolites of BPA. Since it has been observed to have effects on the central nervous system (CNS), we examined the effects of sulfoconjugation on the toxicity of BPA in a human neuroblastoma cell line, NB-1. NB-1 cells showed limited but significant sulfotransferase activity toward BPA in vitro (Km=74μM, Vmax=7.8pmol/min/mg). Accumulation of BPA sulfate was observed for 12hr to 4 days after 10μM BPA was added to a culture of NB-1 cells. These results suggest that BPA is partly detoxified by the sulfoconjugation reaction in human neuronal cells.
- 公益社団法人日本薬学会の論文
- 2003-08-01
著者
-
TAMURA Hiro-omi
Kyoritsu College of Pharacy
-
Ishii Yoshio
Kyoritsu College Of Pharmacy
-
Tamura Hiroomi
Kyoritsu College of Pharmacy
関連論文
- Mg^ Binding and Catalytic Function of Sphingomyelinase from Bacillus cereus
- A Novel Sulfotransferase Abundantly Expressed in the Dauer Larvae of Caenorhabditis elegans
- Cloning, Expression, and Characterization of Cytosolic Sulfotransferase Isozymes from Drosophila melanogaster
- Changes in the Gene Expression of Drug Metabolizing Enzymes during Cataractogenesis in Shumiya Cataract Rats
- Cytochrome P450 (CYP) Expression in Human Myeloblastic and Lymphoid Cell Lines
- Expression Profiling of Sulfotransferases in Human Cell Lines Derived from Extra-Hepatic Tissues
- Region- and Isoform-Specific Expression of Hydroxysteroid Sulfotransferases in Rat Brain
- Identification and Purification of Sulfotransferases for 20-Hydroxysteroid from the Larval Fat Body of a Fleshfly, Sarcophaga peregrina(Biochemistry & Molecular Biology)
- Metabolism of Bisphenol A in the Rat Syncytiotrophoblast Cell Line, TR-TBT 18d-1
- Epigallocatechin Gallate(EGCG)Inhibits the Sulfation of 1-Naphthol in a Human Colon Carcinoma Cell Line, Caco-2
- Inhibitory Effects of Green Tea and Grape Juice on the Phenol Sulfotransferase Activity of Mouse Intestines and Human Colon Carcinoma Cell Line, Caco-2
- Oxidative Stress Induces GSTP1 and CYP3A4 Expression in the Human Erythroleukemia Cell Line, K562 (Biochemistry/Molecular Biology)
- Changes in the Gene Expression Patterns of the Cytochrome P450s in Selenite-induced Cataracts in the Rat
- The Effects of Coffee on Conjugation Reactions in Human Colon Carcinoma Cells(Toxicology)
- Effects of Gonadal Hormones on the Zonal Expression of Rat Hepatic Phenol Sulfotransferases
- Identification and Localization of Two Hydroxysteroid Sulfotransferases in the Human Brain
- Sulfortransferases in a Human Colon Carcinoma Cell Line, Caco-2
- Turmeric and Curcumin Modulate the Conjugation of 1-Naphthol in Caco-2 Cells(Miscellaneous)
- Effect of Herbal Teas on Conjugation Reactions in a Human Colon Carcinoma Cell Line, Caco-2
- Cloning, Expression, and Characterization of Cytosolic Sulfotransferase Isozymes from Drosophila melanogaster
- Cytochrome P450 Expression in Rat Ocular Tissues and Its Induction by Phenobarbital
- Expression Profiling of Drug Metabolizing Enzymes in Rat Syncytiotrophoblast Cell Lines
- Identification of Three Hydroxysteroid Sulfotransferase Isoenzymes in the Rat Liver
- Effects of Phenolic Environmental Estrogens on the Sulfotransferase Activity of the Mouse Intestine and a Human Colon Carcinoma Cell Line, Caco-2
- Cloning and Expression of a Novel Sulfotransferase with Unique Substrate Specificity from Bombyx mori
- Sulfoconjugation of Bisphenol A in a Human Neuroblastoma Cell Line, NB-1