Comparison of Displacemental Potencies of Terazosin Enantiomers for α_1-Adrenoceptor Subtypes
スポンサーリンク
概要
- 論文の詳細を見る
The present study was designed to assess displacemental potencies of terazosin and its isomers for α_<1High> and α_<1Low> adrenoceptor subtypes in rat brain, heart, bovine prostate and canine aorta using a radioligand binding assay method. Although no significant difference in pK_i values of each terazosin isomer for α_<1High> in canine aorta and rat brain were observed, the displacemental potency of (S-) terazosin for those in rat heart and bovine prostate was stronger than that of (R+) isomer (p<0.01). On the other hand, only in α_<1Low> subtypes of bovine prostate was stronger displacemental potency of (S-) terazosin than (R+) isomer (p<0.05) observed. Thus, these results imply that there is a different affinity between (S-) terazosin and (R+) isomer on the α_<1High> in bovine prostate and rat heart and α_<1Low> in bovine prostate.
- 公益社団法人日本薬学会の論文
- 1994-08-15
著者
-
長友 孝文
Department of Pharmacology, Niigata College of Pharmacy
-
長友 孝文
Department Of Pharmacology Niigata College Of Pharmacy
-
丸山 恵子
アリゾナ大学医学部薬理
-
丸山 恵子
Department of Pharmacology, Niigata College of Pharmacy
-
大倉 紀子
Department of Pharmacology, Niigata College of Pharmacy
-
八木 優子
Department of Pharmacology, Niigata College of Pharmacy
-
八木 優子
Department Of Pharmacology Niigata College Of Pharmacy
-
長友 孝文
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And App
-
大倉 紀子
Department Of Pharmacology Niigata College Of Pharmacy
関連論文
- Cardiomyopathic Hamster Hearts : Long-Term Effects of Drugs on Catecholamine Contents and Binding Characteristics of α_1- and β_1-Adrenergic Receptors
- Alterations of Binding Characteristics of α_1-, β_1-Adrenoceptors and Ca^ Binding Sites in the Myocardium of Spontaneously Hypertensive Rats (SHR) by Chronically Administered Bunazosin, Atenolol, Ketanserin and Verapamil
- Binding Characteristics of [^3H] Dihydroalprenolol to β-Adrenergic Receptors of Rat Brain : Comparison with Those of Rat Heart Treated with Neuraminidase
- Effects of Ketanserin and 3-[2-[4-(o-Methoxyphenyl)-1-piperazinyl]ethyl]-2,4(1H, 3H)-quinazolinedione Monohydrochloride (SGB-1534), Anti-hypertensive Agents, on ^3H-Serotonin and ^3H^Ketanserin Bindings to Serotonergic (5HT_1 and 5HT_2) Receptors in Dog B
- Effect of 3-[2-[4-(o-Methoxyphenyl)-1-piperazinyl]ethyl]-2,4(1H, 3H)-quinazolinedione Monohydrochloride (SGB-1534), an Anthihypertensive Agent, on ^3H-Prazosin and ^3H-p-Aminoclonidine Binding to α_1-and α_2-Adrenoceptors in Dog Brain and Arta
- Effects of Choline and Inositol on ^3H-Dihydroalprenolol and ^I-Iodocyanopindolol Bindings to β-Adrenegic Receptors of the Guinea Pig Cerebral Cortical Membranes
- Characterization of ^3H-Dihydroalprenolol Binding to β-Adrenergic Receptors of Rat Brain : Two Binding Sites of Racemic Propranolol in Displacement Experiments(Pharmacological)
- Biphasic Binding of ^I-Iodocyanopindolol to β-Adrenergic Receptors in Rat Cerebral Cortical Membranes. I. Assessment by the Use of Agonists(Pharmacological)
- Adrenergic and Serotonergic Receptor-Blocking Potencies of Terazosin, a New Antihypertensive Agent, as Assessed by Radioligand Binding Assay(Pharmacological)
- 結合実験法によるウシ前立腺におけるα_1-アドレナリン性受容体サブタイプ性状の解析
- ボピンドロール投与による高血圧自然発症ラット(SHR)の心筋α_1-及びβ-受容体の性状変化に関する研究
- The Affinity of Bopindolol and Its Two Metabolites for a β_2-Adrenoceptor in the Bovine Mesenteric Artery
- Comparison of Displacemental Potencies of Terazosin Enantiomers for α_1-Adrenoceptor Subtypes
- Bopindolol Is a Slowly Dissociating β_1-Adrenoceptor Antagonist When Compared to Other β-Blockers