Effect of a Dynorphin A Analog, E2078,on Phospholipid Membrane Properties
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概要
- 論文の詳細を見る
The effect of the Dynorphin A analog, E2078,on the physicochemical properties of lipid membranes was investigated. E2078 induces the leakage of calcein, especially out of negatively-charged vesicles. The peptide binds to dipalmitoylphosphatidylglycerol sonicated vesicles according to the Lamgmuir isotherm, with a binding constant of 4.0×10^5 M^<-1> and a binding -site number of 0.14 per lipid molecule. The leakage seems to occur at a critical binding-site number of approx. 0.025 per lipid molecule. In addition, E2078 increased the membrane fluidity of the acidic lipid bilayer. In conclusion, E2078 interacts with acidic lipids through electrostatic interactions, inducing leakage and increasing membrane fluidity.
- 公益社団法人日本薬学会の論文
- 1999-05-15
著者
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WATANABE Sumio
Tsukuba Research Laboratories, Eisai Co., Ltd.,
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Asai Yasuyuki
Formulation Research Laboratory Kawashima Eisai Co. Ltd.
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Watanabe Sumio
Tsukuba Research Laboratories Eisai Co. Ltd.
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