Formation of Spherical Micelles by the Novel Platelet Activating Factor Receptor Antagonist, E5880
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概要
- 論文の詳細を見る
E5880,a novel platelet activating factor receptor antagonist, was dispersed in water for the preparation of injectable formulation and the physicochemical properties of the micelles were characterized. The critical concentration for formation of micelles was 0.12 mM. Using the area per molecule results, the critical packing parameter was calculated and showed that the structure was composed of spherical micelles and the number of the molecules per micelle was 88. The diameter of a micelle was 8.1 nm. The fluidity and micropolarity around the hydrocarbon region of the micelles were evaluated and compared to the surfactants, stearyltrimethylammmonium chloride and cetyltrimethylammonium chloride.
- 社団法人日本薬学会の論文
- 2000-07-01
著者
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Iwamoto Kiyoshi
Formulation Research Laboratories Kawashima Research Eisai Co. Ltd.
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Iwamoto Kiyoshi
Formulation Research Laboratory Kawashima Eisai Co. Ltd.
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NOMURA Teruko
Formulation Research Laboratory, Kawashima, Eisai Co., Ltd.,
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ASAI Yasuyuki
Formulation Research Laboratory, Kawashima, Eisai Co., Ltd.,
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MURAHASHI Naokazu
Formulation Research Laboratory, Kawashima, Eisai Co., Ltd.,
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Iwamoto Kiyoshi
Formulation Res. Lab. Eisai Co. Ltd.
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Nomura T
Formulation Research Laboratory Kawashima Eisai Co. Ltd.
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Asai Yasuyuki
Formulation Research Laboratory Kawashima Eisai Co. Ltd.
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Murahashi Naokazu
Formulation Research Laboratory Kawashima Eisai Co. Ltd.
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