The Effect of the Lipid A Analog, E5531 on Fever Induced by Endotoxin from Escherichia coli
スポンサーリンク
概要
- 論文の詳細を見る
E5531 is a specific lipid A antagonist and is expected to be a drug for the treatment of septic shock. The LAL (limulus amebocyte lysate) activity and pyrogenicity of E5531 were determined. The LAL activity of E5531 is large and confirmed that E5531 had a high affinity to the lipopolysaccharide receptor. The pyrogenic activity of E5531 is weak and the pyrogenic profile of E5531 is different from that of USP (United States Pharmacopoeia) reference standard endotoxin (ETX). E5531 suppressed the pyrogenicity of ETX in rabbits, indicating that E5531 in expected to be useful for the treatment of fever induced by ETX.
- 社団法人日本薬学会の論文
- 1999-04-15
著者
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Iwamoto Kiyoshi
Formulation Research Laboratories Kawashima Research Eisai Co. Ltd.
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ASAI Yasuyuki
Formulation Research Laboratory, Kawashima, Eisai Co., Ltd.,
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NOZU Yukio
Analytical Research Laboratory, Kawashima, Eisai Co., Ltd.,
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IKEUCHI Takayuki
Analytical Research Laboratory, Kawashima, Eisai Co., Ltd.,
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NARAZAKI Ryuichi
Formulation Research Laboratory, Kawashima, Eisai Co., Ltd.,
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WATANABE Sumio
Tsukuba Research Laboratories, Eisai Co., Ltd.,
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Iwamoto Kiyoshi
Formulation Res. Lab. Eisai Co. Ltd.
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Nozu Yukio
Analytical Research Laboratory Kawashima Eisai Co. Ltd.
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Asai Yasuyuki
Formulation Research Laboratory Kawashima Eisai Co. Ltd.
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Asai Yasuyuki
エーザイ
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Ikeuchi T
Analytical Research Laboratory Kawashima Eisai Co. Ltd.
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Watanabe Sumio
Tsukuba Research Laboratories Eisai Co. Ltd.
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Narazaki Ryuichi
Formulation Research Laboratory Kawashima Eisai Co. Ltd.
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Narazaki Ryuichi
Formulation Research Laboratories, Kawashima Research, Eisai Co., Ltd.
関連論文
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- The Effect of the Lipid A Analog, E5531 on Fever Induced by Endotoxin from Escherichia coli
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- Investigation on the relationship between the physicochemical properties of particles composed of a novel lipid A analog, E5531, and its pharmacokinetics
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