The Interaction of Menaquinone-4 with Phopholipid Membranes
スポンサーリンク
概要
- 論文の詳細を見る
The effects of menaquinone-4 (MQ) on dipalmitoylphosphatidylcholine (DPPC) membranes were studied by surface monolayer and fluorescence techniques. DPPC and MQ have been proven to be freely miscible in the mixed monolayer at an air/water interface, and to be partially miscible in a bulk phase, i.e., the bilayer and solid phase. There is an expanding interaction between MQ and DPPC in the MQ/DPPC mixed monolayer. The solubility of MQ in the DPPC is about 20 mol%, and the solubility of DPPC in MQ is about 10 mol%. The addition of MQ induced a proportional decrease in the phase transition temperature of DPPC membrane and a broadening of the temperature range of the transition.
- 公益社団法人日本薬学会の論文
- 1999-05-15
著者
-
WATANABE Sumio
Tsukuba Research Laboratories, Eisai Co., Ltd.,
-
ASAI Yasuyuki
Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Lid.
-
Asai Yasuyuki
Formulation Research Laboratory Kawashima Eisai Co. Ltd.
-
Watanabe Sumio
Tsukuba Research Laboratories Eisai Co. Ltd.
関連論文
- Formation of Spherical Micelles by the Novel Platelet Activating Factor Receptor Antagonist, E5880
- The Effect of the Lipid A Analog, E5531 on Fever Induced by Endotoxin from Escherichia coli
- Aurantiamide Acetate, a Selective Cathepsin Inhibitor, Produced by Aspergillus penicilloides
- TMC-66, a New Endothelin Converting Enzyme Inhibitor Produced by Streptomyces sp. A5008
- TMC-49A, a Novel Transcriptional Up-Regulator of Low Density Lipoprotein Receptor, Produced by Streptomyces sp. AS1345
- Production of TMC-151, TMC-154 and TMC-171, a new class of antibiotics, is specific to 'Gliocladium roseum' group
- TMC-171A, B, C and TMC-154, Novel Polyketide Antibiotics Produced by Gliocladium sp. TC 1304 and TC 1282
- TMC-2A, -2B and -2C, Novel Dipeptidyl Peptidase IV Inhibitors Produced by Aspergillus oryzae A374 I. Taxonomy of Producing Strain, Fermentation, and Biochemical Properties
- TMC-2A, -2B and -2C, New Dipeptidyl Peptidase IV Inhibitors Produced by Aspergillus oryzae A374 II. Isolation and Structure Determination
- Characterization of the Physicochemical Properties of the Micelle of the Novel Platelet Factor Receptor Antagonist, E5880
- Characterization of the Physicochemical Properties of Micelles of the Novel Platelet Activating Factor Receptor Antagonist, E5880
- Development of Freeze-Dried Injectable Formulation for the Novel Lipid A Analog, E5531
- Cryoprotective Effects of Saccharides on the Freeze-Drying of Sonicated Vesicles of the Lipid A Analog, E5531
- Effects of Calcium Ion on the Physicochemical Properties of Particles of A Lipid A Analog, E5531 and Its Pharmacokinetics in Rats
- Formation of the Dispersed Particles Composed of Soybean Oil and Phosphatidylcholine
- Development of an Injectable Formulation for the Novel Lipid A Analog E5531 Using a`pH-jump Method'
- Interaction of α-Tocopherol Acetate with Phosphatidylcholine and Their Formation of Small Dispersed Particles
- Development of an Injectable Formulation of the Novel Lipid A Analog E5531
- Characterization of the Physicochemical Properties of Micelles Composed of a Novel Platelet Factor Receptor Antagonist, E5880
- The Interaction of Menaquinone-4 with Phopholipid Membranes
- Effect of a Dynorphin A Analog, E2078,on Phospholipid Membrane Properties
- Investigation on the relationship between the physicochemical properties of particles composed of a novel lipid A analog, E5531, and its pharmacokinetics
- Characterization of the Physicochemical Properties of Micelles of the Novel Platelet Activating Factor Receptor Antagonist, E5880
- Cryoprotective Effects of Saccharides on the Freeze-Drying of Sonicated Vesicles of the Lipid A Analog, E5531
- Effects of Calcium Ion on the Physicochemical Properties of Particles of A Lipid A Analog, E5531 and Its Pharmacokinetics in Rats
- Phase Characteristics of Dispersed Particles Composed of Retinal and Dipalmitoylphosphatidylcholine