Distribution of Thyrotropin-Releasing Hormone (TRH) Receptors in the Brain of the Ataxic Mutant Mouse, Rolling Mouse Nagoya
スポンサーリンク
概要
- 論文の詳細を見る
Thyrotropin-releasing hormone (TRH) and its analog, TA-0910,ameliorate the ataxia of the mutant mouse, rolling mouse Nagoya, by metabolic normalization in the ventral tegmental field (VTF). We here investigated the distribution of cerebral TRH receptors in the rolling mouse to clarify the sites of action of these drugs. TRH receptors were widely distributed in multiple brain areas, including in the VTF and the cuneiform nucleus (CnF) which terminates in the VTF. These results suggest that TRH and TA-0910 directly activate the VTF by acting on TRH receptors in the VTF and indirectly activate it through the receptors in the CnF.
- 公益社団法人日本薬学会の論文
- 1997-01-15
著者
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Matsuoka Yuzo
Discovery Researchlaboratory Tanabe Seiyaku Co. Ltd.
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Kawashima K
Nagoya Inst. Of Technol. Nagoya Jpn
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Yamamura Michio
Tanabe R&d Service Co. Ltd.
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KINOSHITA Kiyoshi
Pharmacology Department, Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
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YAMAMURA Michio
Pharmaceutical Development Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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SUGIHARA Juko
Pharmaceutical Development Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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Yamamura Michio
Pharmacology Department Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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Kinoshita Kiyoshi
Pharmacology Department Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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SUGIHARA Juko
Pharmaceutical Development Research Laboratory, Tanabe Seiyaku Co. Ltd.
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Sugihara Juko
Pharmaceutical Development Research Laboratory Tanabe Seiyaku Co., Ltd.,
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