Effects of mafoprazine, a phenylpiperazine derivative, on the central dopaminergic system.
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概要
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The effects of mafoprazine, a new phenylpiperazine derivative, on the central dopaminergic system were studied. Mafoprazine, like chlorpromazine and haloperidol, reduced the apomorphine-induced cage-climbing behavior in mice, emesis in dogs and stereotyped behavior in monkeys; methamphetamine-induced hyperlocomotion and group toxicity in mice; and agitation in rats. Mafoprazine inhibited the unilateral circling behavior induced by methamphetamine and apomorphine in rats with 6-hydroxydopamine-induced lesions in the unilateral nigrostriatal neuronal tract. The potency of mafoprazine in these experiments was almost equal to that of chlorpromazine and about one-tenth that of haloperidol. The cataleptogenic activity of mafoprazine was lower than those of chlorpromazine and haloperidol. Mafoprazine potentiated clonidine-induced hypothermia. These results suggest that mafoprazine has a relatively selective postsynaptic dopamine D<SUB>2</SUB>-receptor blocking action in the nucleus accumbens compared with chlorpromazine and haloperidol and suggest that mafoprazine also has α<SUB>2</SUB>-adrenoceptor-stimulating actions.
- 公益社団法人 日本薬理学会の論文
著者
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ISHIDA Ryuichi
Pharmacological Research Laboratory Tanabe Seiyaku Co., Ltd.
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YAMAMURA Michio
Pharmaceutical Development Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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Kinoshita Kiyoshi
Pharmacology Department Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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MAEDA Kayoko
Pharmacology Department, Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
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NAKAGAWA Hiroyuki
Pharmacology Department, Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
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YAMAMURA Michio
Pharmacology Department, Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
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