No Relation of the Suppressive Effect on the Sympathetic Nervous System to the Acute Hypotension Caused by Imidapril and Enalapril.

スポンサーリンク

概要

• 論文の詳細を見る

• To investigate the involvement of the sympathoinhibitory effect of imidapril and enalapril in their antihypertensive effect at a clinically reasonable dose, we studied whether some responses induced by the stimulation of the sympathetic nervous system (SNS) were affected by intravenous administration of imidaprilat and enalaprilat in curarized pithed spontaneously hypertensive rats. Imidaprilat and enalaprilat (both at 100 μg/kg, i.v.), which are active metabolites of imidapril and enalapril, respectively, suppressed the pressor responses to electrical stimulation (ES) of the spinal cord (T<SUB>1</SUB>-L<SUB>7</SUB>) and exogenous noradrenaline (NA). The pressor responses to NA were significantly suppressed after either α<SUB>1</SUB> or α<SUB>2</SUB>-adrenoceptors were blocked. Furthermore, imidaprilat (100 μg/kg, i.v.) suppressed these reduced responses. When the reduced basal blood pressure was restored by vasopressin infusion, imidaprilat and enalaprilat (both at 100 μg/kg, i.v.) did not suppress the responses to ES and exogenous α-adrenoceptor agonists. They affected neither basal plasma concentrations of NA and adrenaline nor ES-induced increase of these catecholamines. These results suggest that the suppressive effects of imidaprilat and enalaprilat on the pressor responses to ES and α-adrenoceptors agonists are apparently observed in pithed SHR because of a reduction of vascular tone and that imidapril and enalapril do not lower the blood pressure through suppressing SNS.

• 公益社団法人 日本薬理学会の論文

著者

• ISHIDA Ryuichi

  Pharmacological Research Laboratory Tanabe Seiyaku Co., Ltd.

• Sumikawa Hiroshi

  Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd.

• Ogiku Noriko

  Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.

関連論文

• Effects of Long-Term Administration of (4S)-1-Methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl) amino] propionyl}-2-oxoimidazolidine-4-carboxylic Acid Hydrochloride (TA-6366), a New Angiotensin I Converting Enzyme (ACE) Inhibitor, from the Pre-hy
• Effects of mafoprazine, a phenylpiperazine derivative, on the central dopaminergic system.
• Reduction of the Mortality Rate by Imidapril in a Small Coronary Artery Disease Model, (NZW*BXSB)F1 Male Mice.
• Histopathological Investigation on Salt-Loaded Stroke-Prone Spontaneously Hypertensive Rats, Whose Biochemical Parameters of Renal Dysfunction Were Ameliorated by Administration of Imidapril.
• A behavioral pharmacological study of mafoprazine, a new phenylpiperazine derivative.
• Neurochemical study of mafoprazine, a new phenylpiperazine derivative.
• Influence of Imidapril on Abnormal Biochemical Parameters in Salt-Loaded Stroke-Prone Spontaneously Hypertensive Rats(SHRSP).
• No Relation of the Suppressive Effect on the Sympathetic Nervous System to the Acute Hypotension Caused by Imidapril and Enalapril.

スポンサーリンク