Protective Effect of Fluvastatin on Degradation of Apolipoprotein B by a Radical Reaction in Human Plasma
スポンサーリンク
概要
- 論文の詳細を見る
Fluvastatin, which is a synthetic 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase inhibitor, its metabolites (M2, M3 and M4) and trolox all inhibited the decrease of apolipoprotein B-100 (apoB) and α-tocopherol in a radical reaction of human plasma initiated by Cu^<2+>. The concentrations of fluvastatin, M2, M3, M4 and trolox for 50% inhibition (IC_<50>) of apoB fragmentation were 405, 8.55, 1.75, 305, and 43.4μM, respectively. The IC_<50> value of pravastatin, which is another HMG-CoA reductase inhibitor, was 2880μM, showing that pravastatin is not an effective antioxidant. Although fluvastatin, its metabolites and trolox inhibited the decrease of α-tocopherol in a similar manner to that of apoB, pravastatin did not significantly inhibit the decrease of α-tocopherol. Since oxidation of low density lipopotein (LDL) is an important step in the initiation and progression of atherosclerosis, fluvastatin may reduce the risk of atherosclerosis not only by lowering plasma cholesterol but also by protecting LDL from oxidation.
- 公益社団法人日本薬学会の論文
- 2001-02-01
著者
-
Ikeda Kazumi
Laboratory Tanabe Seiyaku Co. Ltd.
-
Aoki Shoichi
Tanabe R&d Service Co. Ltd.
-
Kojo Shosuke
Science And Nutrition Nara Women's University
-
Matsuoka Yuzo
Discovery Researchlaboratory Tanabe Seiyaku Co. Ltd.
-
Yamamura Michio
Tanabe R&d Service Co. Ltd.
-
Yamamura Michio
Pharmacology Department Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
-
Yamamura Michio
Tanabe R&d Co. Ltd.
関連論文
- Stereoselective Pharmacokinetics of RS-8359,A Selective and Reversible Inhibitor of A-Type Monoamine Oxidase, in Rats, Mice, Dogs, and Monkeys
- Quantitative determination of diol metabolites of CS-670, a new antiinflammatory agent, by capillary column gas chromatography-mass spectrometry
- L-Type amino acid transporter 1 inhibitors inhibit tumor cell growth
- Protective Effect of Fluvastatin on Degradation of Apolipoprotein B by a Radical Reaction in Human Plasma
- Metabolic Abnormalities Caused by 3-Acetylpyridine in the Cerebral Motor Regions of Rats: Partial Recovery by Thyrotropin-Releasing Hormone
- Diversity of Thyrotropin-Releasing Hormone Receptors in the Pituitaryand Discrete Brain Regions of Rats
- Distribution of Thyrotropin-Releasing Hormone (TRH) Receptors in the Brain of the Ataxic Mutant Mouse, Rolling Mouse Nagoya
- Chronic Anti-ataxic Actions of the Novel Thyrotropin-Releasing Hormone (TRH) Analog, TA-0910,during and after Repeated Administration in Rolling Mouse Nagoya : Behavioral and Pharmacokinetic Studies
- Effect of TA-0910, a Novel Thyrotropin-Releasing Hormone Analog, on In Vivo Acetylcholine Release and Turnover in Rat Brain