THE DEVELOPMENT OF A NONLINEAR MODEL TO DESCRIBE THE BLOOD GLUCOSE RESPONSE FOR THE DETERMINATION OF PRANDIAL INSULIN INFUSION

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概要

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• We studied the relationship between the rate of intravenous glucose infusion and the blood glucose concentration at two different physiological levels of hyperinsulinemia in a depancreatized dog. The same degree of changes in the glucose infusion rate generated progressively larger increments in the blood glucose concentration. We then developed a Michaelis-Menten type kinetic model which could appropriately describe this nonlinear relationship of blood glucose response under the condition of hyperinsulinemia. In oder to determine the prandial insulin infusion program, we used more simplified equations based on a nonlinear model. The simplified equations were demonstrated to be applicable for estimating the prandial subcutaneous insulin infusion program in the continuous subcutaneous insulin infusion system.

• 公益社団法人日本薬学会の論文

著者

• Kasuya Y

  Department Of Pharmacology Hoshi University School Of Pharmaceutical Sciences

• KASUYA YASUJI

  Department of Clinical Pharmacy, Tokyo College of Pharmacy

• KATAKURA TAKEO

  Medical Devices and Artificial Organs Section, Technical R and D Division, Terumo Corporation

• Kasuya Yasuji

  Department Of Clinical Pharmacy Tokyo College Of Pharmacy

• Katakura Takeo

  Medical Devices And Artificial Organs Section Technical R And D Division Terumo Corporation

• Yagishita A

  Tokyo Metropolitan Neurological Hospital Tokyo

• Hirayama H

  Reproductive Biotechnology Lab. Hokkaido Animal Res. Center Hokkaido Jpn

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