EVALUATION OF THE BOLIE MODEL DESCRIBING BLOOD GLUCOSE RESPONSE FOR THE APPLICATION TO CONTINUOUS SUBCUTANEOUS INSULIN INFUSION

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概要

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• In an attempt to develop an appropriate infusion program in a continuous subcutaneous insulin infusion system, a conventional pharmacodynamic model (the Bolie model) for describing the relationship between blood glucose and serum insulin levels was evaluated, using a depancreatized dog preparation. The Bolie model was found useful in estimating the basal insulin infusion rate. However, the model could not predict the serum insulin concentration-time profile required to maintain the postprandial blood glucose levels within a physiological range. It will be necessary to develop a more appropriate model for determining the prandial subcutaneous insulin infusion rates in the continuous subcutaneous insulin infusion system.

• 公益社団法人日本薬学会の論文

著者

• Kasuya Y

  Department Of Pharmacology Hoshi University School Of Pharmaceutical Sciences

• KASUYA YASUJI

  Department of Clinical Pharmacy, Tokyo College of Pharmacy

• KATAKURA TAKEO

  Medical Devices and Artificial Organs Section, Technical R and D Division, Terumo Corporation

• Kasuya Yasuji

  Department Of Clinical Pharmacy Tokyo College Of Pharmacy

• Katakura Takeo

  Medical Devices And Artificial Organs Section Technical R And D Division Terumo Corporation

• Yagishita A

  Tokyo Metropolitan Neurological Hospital Tokyo

• Hirayama H

  Reproductive Biotechnology Lab. Hokkaido Animal Res. Center Hokkaido Jpn

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