Clastogenicity of Aporphine Alkaloids in Vitro
スポンサーリンク
概要
- 論文の詳細を見る
The chromosomal aberration test using a Chinese hamster lung cell line (CHL) was carried out on 19 aporphine alkaloids including apomorphine with and without rat liver homogenates (S9) mix. Einghteen of 19 alkaloids tested induced chromosomal aberration in the presence of absence of S9 mix. Among the alkaloids tested, anolobine, liriodenine and 4,5-dioxodehydrocrebanine induced chromosomal aberrations at relatively low concentrations and as low as 2.5,5 and 3.13 μg/ml, respectively. Dicentrine, anolobine and 4,5-dioxodehydrocrebanine induced chromosomal aberrations with high frequencies, Apomorphine induced 10% aberrant cells at 12.5 μg/ml in the direct method and 12% at 100 μg/ml with S9 mix in the S9 method. Liriodenine which was the most potent mutagen for TA100 with S9 mix and roemerine which was the most potent for TA98 with S9 mix in Ames test were also clastogenic with and without S9 mix.
- 公益社団法人日本薬学会の論文
著者
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Morimoto Isao
First Department Of Internal Medicine School Of Medicine University Of Occupational And Environmenta
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Morimoto I
Asahi Chemical Industry Co. Ltd. Shizuoka
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Morimoto Isao
Optical Disks Development Department Division Of Information And Devices Technologie
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MORIMOTO ISAO
Saitama Prefectual Institute of Public Health
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Morimoto I
First Department Of Internal Medicine School Of Medicine University Of Occupational And Environmenta
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Morimoto Isao
Saitama Institute Of Public Health:faculty Of Pharmaceutical Sciences Mukogawa Women's Universi
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TADAKI Shinichi
Saitama Institute of Public Health
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NOZAKA Tomio
Saitama Institute of Public Health
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YAMADA Sayuri
Saitama Institute of Public Health
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ISHINO Masazo
Saitama Institute of Public Health
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TANAKA Akio
Saitama Institute of Public Health
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KUNITOMO Junichi
Saitama Institute of Public Health
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Yamada S
Saitama Institute Of Public Health:faculty Of Pharmaceutical Sciences Mukogawa Women's Universi
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Nozaka T
Saitama Institute Of Public Health:faculty Of Pharmaceutical Sciences Mukogawa Women's Universi
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Ishino Masazo
Saitama Institute Of Public Health:faculty Of Pharmaceutical Sciences Mukogawa Women's Universi
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Tadaki Shinichi
Saitama Institute Of Public Health:faculty Of Pharmaceutical Sciences Mukogawa Women's Universi
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Kunitomo Junichi
Saitama Institute Of Public Health:faculty Of Pharmaceutical Sciences Mukogawa Women's Universi
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Tanaka Akio
Saitama Institute Of Public Health:faculty Of Pharmaceutical Sciences Mukogawa Women's Universi
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