Desmutagenicity of Clove Extracts on Trp-P-2-induced Mutagenesis in Salmonella typhimurium TA 98
スポンサーリンク
概要
- 論文の詳細を見る
Trp-P-2 (3-amino-l-methyl-5H-pyrido [4, 3-b] indole) shows activities when activated by the microsomes of rat-liver homogenate. In this work, the inhibitory effect of clove extract on such mutagenic activities was investigated by both the desmutagenicity test and the bio-antimutagenicity test using Ames/Salmonella typhimuriwn strain TA 98 and high pressure liquid chromatographic (HPLC) analysis of the mutagenic metabolite (3-hydroxyamino-l-methyl-5H-pyrido [4, 3-b] indole) produced in Trp-P-2 metabolism. Of the four fractions prepared from clove bud extracts, the hot water extract fraction and the water soluble fraction, both containing tannin, were proved to be desmutagenic: they inhibited the metabolic activation of Trp-P-2 and almost completely inactivated the mutagenic metabolite produced. The ether soluble fraction containing eugenol had the desmutagenic effect: it inhibited the Trp-P-2 metabolism only. The tannin free fraction was almost completely ineffective. None of the fractions were proved to be bio-antimutagenic.
- 日本生薬学会の論文
- 1989-12-20
著者
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Morimoto Isao
First Department Of Internal Medicine School Of Medicine University Of Occupational And Environmenta
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Morimoto Isao
Saitama Institute Of Public Health:faculty Of Pharmaceutical Sciences Mukogawa Women's Universi
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NOZAKA Tomio
Saitama Institute of Public Health
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Morimoto I
First Department Of Internal Medicine School Of Medicine University Of Occupational And Environmenta
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Nozaka Tomio
Saitama Prefectural Institute Of Public Health
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Tadaki Shin-ichi
Saitama Prefectural Institute Of Public Health
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WATANABE FUJIO
Saitama Prefectural Institute of Public Health
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