Mutagenic Activities of Bellidifolin, Methylbellidifolin, and Methylswertianin in the Methanol Extract from Swertiae Herba (Gentianaceae)

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概要

• 論文の詳細を見る

• Three substances showing mutagenic activity in Salmonella typhimurium TA100 with S9 mix were isolated from methanol extract of Swertiae Herba (Gentianaceae) by conventional techniques, and were identified on the basis of analytical and spectral data as methylbellidifolin, methylswertianin, and bellidifoin. Their specific mutagenic activities of methylbellidifolin, methylswertianin, and bellidifolin expressed in terms of the number of the revertant colonies per pg were 17.8, 6.9, and 30.4, respectively. The mutagenic activity shown by Swertiae Herba may be considered mainly to be due to bellidifolin, because it is the major hydroxyxanthone (91% of the total hydroxyxanthones content) in Swertiae Herba and has higher specific mutagenic activity.

• 日本生薬学会の論文
• 1984-03-20

著者

• OKITSU TOMOAKI

  Saitama Prefectual Institute of Public Health

• Morimoto Isao

  Saitama Institute Of Public Health:faculty Of Pharmaceutical Sciences Mukogawa Women's Universi

• NOZAKA Tomio

  Saitama Institute of Public Health

• WATANABE FUJIO

  Saitama Prefectural Institute of Public Health

• MORIMOTO ISAO

  Saitama Prefectural Institute of Public Health

関連論文

• Formation of Cyanogen Chloride through Chlorination of Waste Waters Related to the Fish Market (Regular Presentations) (Proceedings of the 15 th Symposium on Environmental Pollutants and Toxicology)
• Clastogenicity of Aporphine Alkaloids in Vitro
• Desmutagenicity of Clove Extracts on Trp-P-2-induced Mutagenesis in Salmonella typhimurium TA 98
• Mutagenic Activities of Bellidifolin, Methylbellidifolin, and Methylswertianin in the Methanol Extract from Swertiae Herba (Gentianaceae)

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