INHIBITION OF MUTAGENICITY BY GLYCYRRHIZA EXTRACT AND GLYCYRRHIZIN

概要

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The effects of Glycyrrhiza extract and one of its components, glycyrrhizin, on the mutagenicities of several mutagens were investigated by means of a modification of the Ames test. Both inhibited the mutagenicities of 3-amino-1,4-dimethyl-5 H-pyrido [4,3-b]-indole (Trp-P-1) and 3-amino-1-methyl-5H-pyrido [4,3-b] indole. Since the Glycyrrhiza extract and glycyrrhizin inhibited the mutagenicity of activated Trp-P-1,it was clear that their inhibitory effects were not due to inhibition of the enzyme activity of the S9 fraction. Both Glycyrrhiza extract and glycyrrhizin also inhibited the mutagenicities of benzo [α] pyrene, 3-methylcholanthrene, 2-naphthylamine, 2-amino-6-methyldipyrido [1,2-α : 3', 2'-d]-imidazole, dimethylnitrosoamine and dimethylaminoazobenzene. The mutagenicity of 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (AF-2) was inhibited by the Glycyrrhiza extract but not by glycyrrhizin. This suggested that a component different from glycyrrhizin, present in the Glycyrrhiza extract, inhibited the mutagenicity of AF-2.
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