Determination of Secnidazole in Urine by Adsorptive Stripping Voltammetry
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概要
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Cyclic voltammetry was used to explore the adsorption behavior of secnidazole on a hanging mercury drop electrode (HMDE). The effects of various operational parameters on the accumulation behavior of the adsorbed species were tested. Thus, a sensitive stripping voltammetry procedure for the determination of secnidazole with an adsorptive accumulation on the surface of HMDE has been developed. Measurements were taken by differential-pulse voltammetry after determination of the optimum conditions. The linear concetration range was 1×10^<-8>-1×10^<-7>M when using a 120 s preconcentration at -0.1 V vs. Ag/AgCl in acetate buffer of pH 4.0. The detection limit of secnidazole was 5×10^<-9>M. The precision, expressed by the coefficient of variation, was 2.5% (n=10) at a concentration of 1×10^<-7>M. The method was successfully applied to the analysis of secnidazole in urine.
- 公益社団法人日本薬学会の論文
- 2000-05-01
著者
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Hassanein Amira
Department Of Chemistry Faculty Of Science Tanta University
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Radi Abd-elgawad
Dep. Of Chemistry Fac. Of Sci. (dumyat) Mansoura Univ.
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Radi Abd-elgawad
Department Of Chemistry Faculty Of Science (dumyat) Mansoura University
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- Determination of Secnidazole in Urine by Adsorptive Stripping Voltammetry
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