Electrochemical Study of the Antineoplastic Agent Etoposide at Carbon Paste Electrode and Its Determination in Spiked Human Serum by Differential Pulse Voltammetry

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概要

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• The electrochemical oxidation of the antineoplastic agent etoposide was studied at carbon paste electrode in Britton-Robinson buffer solutions over the pH range 2.0-10.0 using cyclic, linear sweep and differential pulse voltammetry. Oxidation of the drug was effected in a single reversible, diffusion-controlled step within the pH range 2.0-4.0, a second oxidation process was produced above pH 4.0. Using differential pulse voltammetry (DPV), the drug yielded a well-defined voltammetric response in Britton-Robinson buffer, pH 3.0 at 0.500 V (vs. Ag/AgCl) on carbon paste electrode. This process could be used to determine etoposide concentrations in the range 2.5×10^<-7> to 2.5×10^<-5>M with a detection limit of 1.0×10^<-7>M. The method was successfully applied to the determination of the drug in spiked human serum.

• 公益社団法人日本薬学会の論文
• 2007-09-01

著者

• Radi Abd-elgawad

  Department Of Chemistry Faculty Of Science (dumyat) Mansoura University

• ABD-ELGHANY Nadia

  Department of Chemistry, Faculty of Education, Suez Canal University

• WAHDAN Tarek

  Department of Chemistry, Faculty of Education, Suez Canal University

• Wahdan Tarek

  Department Of Chemistry Faculty Of Education Suez Canal University

• Abd-elghany Nadia

  Department Of Chemistry Faculty Of Education Suez Canal University

関連論文

• Cathodic Adsorptive Stripping Square-Wave Voltammetry of the Anti-inflammatory Drug Meloxicam
• Determination of Secnidazole in Urine by Adsorptive Stripping Voltammetry
• Electrochemical Study of the Antineoplastic Agent Etoposide at Carbon Paste Electrode and Its Determination in Spiked Human Serum by Differential Pulse Voltammetry
• Electrochemical Study of Zolpidem at Glassy Carbon Electrode and Its Determination in a Tablet Dosage Form by Differential Pulse Voltammetry

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