Electrochemical Study of Zolpidem at Glassy Carbon Electrode and Its Determination in a Tablet Dosage Form by Differential Pulse Voltammetry

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概要

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• The oxidative behaviour of, a hypnotic drug, zolpidem was studied at glassy carbon electrode in Britton-Robinson buffer over the pH range 2.0-11.0 using cyclic, linear sweep and differential pulse voltammetry. Oxidation of the drug was effected in a single irreversible, diffusion-controlled step. Using differential pulse voltammetry (DPV), the drug yielded a well-defined voltammetric response in Britton-Robinson buffer, pH 8.0 at +0.889 V (vs. Ag/AgCl) on glassy carbon electrode. This process could be used to determine zolpidem concentrations in the range 5.0×10^<-7> M to 1.0×10^<-5> M with a detection limit of 2.0×10^<-7> M. The method was applied, without any interference from the excipients, to the determination of the drug in a tablet dosage form.

• 公益社団法人日本薬学会の論文
• 2004-09-01

著者

• Radi A‐e

  Department Of Chemistry Faculty Of Science (dumyat) Mansoura University

• Radi Abd-elgawad

  Department Of Chemistry Faculty Of Science (dumyat) Mansoura University

• WAHDAN Tarek

  Department of Chemistry, Faculty of Education, Suez Canal University

• Wahdan Tarek

  Department Of Chemistry Faculty Of Education Suez Canal University

• BEKHIET Gamal

  Department of Chemistry, Faculty of Science (Dumyat), Mansoura University

• Bekhiet Gamal

  Department Of Chemistry Faculty Of Science (dumyat) Mansoura University

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• Electrochemical Study of Zolpidem at Glassy Carbon Electrode and Its Determination in a Tablet Dosage Form by Differential Pulse Voltammetry

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