Reductive Removal of Sulfonyl Groups : Cleavage of Sulfonamides and Sulfonates by Alkali Metal combined with Crown Ether

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概要

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• A system of potassium metal-crown ether-diglyme has been proved to be highly effective for reductive removal of the sulfonyl group from O-sulfonates or sulfonamides. The reaction proceeds even with mesylamides of dialkyl amines, which resist reductive cleavage by naphthalene radical anion. It has also been found that a simple combination of potassium metal or sodium-potassium alloy with isopropanol in diglyme or toluene is effective for the cleavage of dialkylamine sulfonamides which are relatively susceptible to reduction. In particular, the use of sodium-potassium alloy gave satisfactory results.

• 公益社団法人日本薬学会の論文
• 1982-09-25

著者

• 大石 武

  The Institute of Physical and Chemical Research (Riken)

• 高橋 康雄

  The Institute Of Physical And Chemical Research (riken)

• 大澤 富彦

  The Institute of Physical and Chemical Research (RIKEN)

• 高垣 隆

  The Institute of Physical and Chemical Research (RIKEN)

• 池原 文明

  The Institute of Physical and Chemical Research (RIKEN)

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