Reactions of Lactonic Compounds with Nitrogen-containing Reagents. I. Reaction of Byakangelicol with Dimethylamine and Piperidine
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概要
- 論文の詳細を見る
Byakangelicol (I) was treated with dimethylamine or piperidine in benzene below 60°(condition A), in methanol near room temperature (condition B), and in benzene in a sealed tube at 125°(condition C). Amine amides (VIII and IX), neutral amides (X and XII), and neutral amides (XI and XIII) were obtained under conditions A, B, and C, respectively. Results of ultraviolet and nuclear magnetic resonance measurements and chemical treatment showed that X-XI and XII-XIII were in geometrical relationship, X and XII being cis isomers and XI and XIII trans isomers. An equilibrium between XII and XIII in a 87 : 13 ratio was established within 25 hr when either XII or XIII in 0.1N NaOH-EtOH was exposed to diffused light.
- 公益社団法人日本薬学会の論文
- 1970-12-25
著者
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村井 博
Research Laboratories Nippon Shinyaku Co. Ltd. Klinge Pharma Gmbh And Co.
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村山 正雄
Research And Development Laboratory Nippon Shinyaku Co. Ltd.
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仙福 健治
Research Laboratories, Nippon Shinyaku Co., Ltd. Klinge Pharma GmbH and Co.
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角倉 達朗
Research and Development Laboratory, Nippon Shinyaku Co., Ltd.
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仙福 健治
Research Laboratories Nippon Shinyaku Co. Ltd.
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角倉 達朗
Research And Development Laboratory Nippon Shinyaku Co. Ltd.
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- Reactions of Lactonic Compounds with Nitrogen-containing Reagents. I. Reaction of Byakangelicol with Dimethylamine and Piperidine
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