Synthesis of 1-Isoquinolylacetic Acid Derivatives.

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概要

• 論文の詳細を見る

• Isoquinoline cyclization of N-(3,4-dimethoxyphenethyl)-2-ethoxycarbonylacetamide and 2-alkyl and 2-dialkyl derivatives was studied. Contrary to expectations, the cyclization of dialkyl-substituted acetamide derivatives proceeded most smoothly with excellent yield of the product. One of such products, ethyl α, α-diethyl-α-(6,7-dimethoxy-3,4-dihydro-1-isoquinolyl) acetate, resisted all attempts at dehydrogenation and the starting dihydro base was recovered quantitatively. β-Diethylaminoethyl α, α-diethyl-α-(6,7-dimethoxy-3,4-dihydro-1-isoquinolyl) acetate was also prepared for pharmacological evaluation.

• 公益社団法人日本薬学会の論文
• 1958-04-20

著者

• 村山 正雄

  Research And Development Laboratory Nippon Shinyaku Co. Ltd.

• 村山 正雄

  Pharmaceutical Institute, Medical Faculty, University of Tokyo

関連論文

• Reactions of Lactonic Compounds with Nitrogen-containing Reagents. II. Reaction of Meranzin with Dimethylamine or Piperidine
• Reactions of Lactonic Compounds with Nitrogen-containing Reagents. I. Reaction of Byakangelicol with Dimethylamine and Piperidine
• Synthetic Studies on Suberosin and Osthol
• Synthesis of Homoesermethole.
• Synthesis of dl-Esermethole.
• Synthesis of 1-tert-Alkyl-6,7-dimethoxyisoquinolines.
• Synthesis of 1-Isoquinolylacetic Acid Derivatives.

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