Synthesis of 1-tert-Alkyl-6,7-dimethoxyisoquinolines.

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概要

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• A series of 1-tert-alkyl-6,7-dimethoxy-3,4-dihydroisoquinolines was synthesized in high yields by cyclizing N-(3,4-dimethoxyphenethyl)-2,2,2-trialkylacetamides with phosphoryl chloride. They were dehydrogenated over palladium-carbon only under strenuous conditions to furnish the corresponding isoquinolines. Their spasmolytic activity will be examined. A general procedure for the preparation of trialkylacetic acids of high purity was also described.

• 公益社団法人日本薬学会の論文
• 1958-04-20

著者

• 村山 正雄

  Research And Development Laboratory Nippon Shinyaku Co. Ltd.

• 村山 正雄

  Pharmaceutical Institute, Medical Faculty, University of Tokyo

関連論文

• Reactions of Lactonic Compounds with Nitrogen-containing Reagents. II. Reaction of Meranzin with Dimethylamine or Piperidine
• Reactions of Lactonic Compounds with Nitrogen-containing Reagents. I. Reaction of Byakangelicol with Dimethylamine and Piperidine
• Synthetic Studies on Suberosin and Osthol
• Synthesis of Homoesermethole.
• Synthesis of dl-Esermethole.
• Synthesis of 1-tert-Alkyl-6,7-dimethoxyisoquinolines.
• Synthesis of 1-Isoquinolylacetic Acid Derivatives.

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