Synthesis and Biological Activity of the Metabolites of Diethyl 4-[(4-Bromo-2-cyanophenyl)carbamoyl]benzylphosphonate (NO-1886)
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概要
- 論文の詳細を見る
Five metabolites of diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate (NO-1886) (1) were synthesized to confirm their proposed structures. The metabolites (2-6) were found to be identical with the synthesized compounds. These metabolites were orally administrated to Triton WR-1339-induced hypertriglyceridemic rats, and the plasma levels of triglycerides were measured to estimate lipoprotein lipase activity. All the metabolites showed lower potency than NO-1886.
- 公益社団法人日本薬学会の論文
- 1996-03-15
著者
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Morioka Yujiro
Naruto Research Institute Laboratory Of Drug Metabolism Research Otsuka Pharmaceutical Factory Inc.
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Naito Shinsaku
Naruto Research Institute Laboratory Of Drug Metabolism Research Otsuka Pharmaceutical Factory Inc.
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Nakamura Shizuo
Ulvac Japan Ltd.
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Nakamura Shizuo
Naruto Research Institute Laboratory Of Drug Metabolism Research Otsuka Pharmaceutical Factory Inc.
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TSUTSUMI Kazuhiko
Nutrition Research Institute, Otsuka Pharmaceutical Factory Inc.,
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GOTO Kiyoto
Naruto Research Institute, Laboratory of Drug Metabolism Research Otsuka Pharmaceutical Factory, Inc
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KONDO Mitsuyoshi
Naruto Research Institute, Laboratory of Drug Metabolism Research Otsuka Pharmaceutical Factory, Inc
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Tsutsumi K
Otsuka Pharmaceutical Fac. Inc. Tokushima Jpn
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Goto Kiyoto
Naruto Research Institute Laboratory Of Drug Metabolism Research Otsuka Pharmaceutical Factory Inc.
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Kondo Mitsuyoshi
Naruto Research Institute Laboratory Of Drug Metabolism Research Otsuka Pharmaceutical Factory Inc.
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