Exercise Improved Accumulation of Visceral Fat and Simultaneously Impaired Endothelium-Dependent Relaxation in Old Rats
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概要
- 論文の詳細を見る
Exercise decreases plasma total cholesterol and triglycerides, and simultaneously, increases high density lipoprotein (HDL) cholesterol. Furthermore, it has been reported that exercise improves insulin resistance. As a result, exercise is believed to aid in preventing atherosclerosis. However, we do not know whether exercise protects against the development of atherosclerosis in the elderly. The aim of this study was to ascertain whether exercise prevented atherosclerosis in aorta of old rats. Exercise for three months did not affect plasma lipid levels but decreased accumulation of visceral fat and body weight without the reduction of food intake in two year old rats. Exercise also decreased triglycerides in liver and gastrocnemius white muscle. Exercise resulted in an elevation of plasma lipid peroxide (LPO) levels without affecting superoxide dismutase (SOD). Exercise impaired the endothelium-dependent relaxation of the thoracic aorta caused by acetylcholine in old rats. In summary, the results of our study indicate that exercise induces the reduction of visceral fat, body weight and triglyceride contents in tissues in old rats. These results seems to show that exercise improves insulin resistance. However, exercise simultaneously may cause impaired endothelium-dependent relaxation by elevation of LPO in old rats.
- 公益社団法人日本薬学会の論文
- 2001-01-01
著者
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Nakaya Y
Department Of Nutrition And Metabolism University Of Tokushima Graduate School
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Nakaya Yutaka
Department Of Nutrition School Of Medicine The University Of Tokushima
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Nakaya Yutaka
Department Of Nutrition And Metabolism Graduate School Of Nutrition And Bioscience The University Of
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Sakamoto Saori
Department Of Molecular Medicinal Sciences Graduate School Of Biomedical Sciences Nagasaki Universit
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Sakamoto S
Department Of Molecular Medicinal Sciences Graduate School Of Biomedical Sciences Nagasaki Universit
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Hara T
The First Department Of Internal Medicine Aichi Medical University
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Nakaya Y
Department Of Nutrition And Metabolism Institute Of Health Biosciences The University Of Tokushima G
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Sakamoto S
Department Of Bioengineering Faculty Of Bioscience And Biotechnology Tokyo Institute Of Technology
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TSUTSUMI Kazuhiko
Nutrition Research Institute, Otsuka Pharmaceutical Factory Inc.,
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OKADA Kazuko
Department of Nutrition, School of Medicine, the University of Tokushima
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OHNAKA Masaharu
Department of Nutrition, School of Medicine, the University of Tokushima
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SAKAMOTO Sadaichi
Department of Nutrition, School of Medicine, the University of Tokushima
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KUSUNOKI Masataka
The First Department of Internal Medicine, Aichi Medical University
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HARA Tsutomu
The First Department of Internal Medicine, Aichi Medical University
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Okada Kazuko
Department Of Nutrition The University Of Tokushima School Of Medicine
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Tsutsumi Kazuhiko
大塚製薬工場栄養研究所
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Kusunoki Masataka
The First Department Of Internal Medicine Aichi Medical University
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Okada K
Department Of Applied Chemistry Okayama University
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Ohnaka M
Department Of Nutrition School Of Medicine The University Of Tokushima
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Subhadhirasakul Sanan
Department Of Pharmaceutical Botany And Pharmacognosy Faculty Of Pharmaceutical Sciences Prince Of S
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