Clinical Efficacy of Efonidipine Hydrochloride, a T-type Calcium Channel Inhibitor, on Sympathetic Activities : Examination Using Spectral Analysis of Heart Rate/Blood Pressure Variabilities and ^123I-Metaiodobenzylguanidine Myocardial Scintigraphy
スポンサーリンク
概要
- 論文の詳細を見る
Dihydropyridine Ca antagonists cause reflex tachycardia related to their hypotensive effects. Efonidipine hydrochloride has inhibitory effects on T-type Ca channels, even as it inhibits reflex tachycardia. In the present study, the influence of efonidipine hydrochloride on heart rate and autonomic nervous function was investigated. Using an electrocardiogram and a tonometric blood pressure measurement, autonomic nervous activity was evaluated using spectral analysis of heart rate/systolic blood pressure variability. Three protocols were used: (1) a single dose of efonidipine hydrochloride was administered orally to healthy subjects with resting heart rate values of 75 beats/min or more (high-HR group) and to healthy subjects with resting heart rate values less than 75 beats/min (low-HR group); (2) efonidipine hydrochloride was newly administered to untreated patients with essential hypertension, and autonomic nervous activity was investigated after a 4-week treatment period; and (3) patients with high heart rate values (≥75 beats/min) who had been treated with a dihydropyridine L-type Ca channel inhibitor for 1 month or more were switched to efonidipine hydrochloride and any changes in autonomic nervous activity were investigated. In all protocols, administration of efonidipine hydrochloride decreased the heart rate in patients with a high heart rate, reduced sympathetic nervous activity, and enhanced parasympathetic nervous activity. In addition, myocardial scintigraphy with ^123I-metaiodobenzylguanidine showed significant improvement in the washout rate and H/M ratio of patients who were switched from other dihydropyridine Ca antagonists to efonidipine hydrochloride. Efonidipine hydrochloride inhibits increases in heart rate and has effects on the autonomic nervous system. It may be useful for treating hypertension and angina pectoris, and may also have a cardiac protective function.
- 社団法人日本循環器学会の論文
- 2003-01-20
著者
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ITO Susumu
Department of Neurosurgery, Kanagawa Childrens Medical Center
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Ito S
Department Of Digestive And Cardiovascular Medicine University Of Tokushima Graduate School
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Uehara Kohzo
徳島県立三好病院 内科
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Harada Kenji
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Uehara Kohzou
Department Of Digestive And Cardiovascular Medicine School Of Medicine University Of Tokushima
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Nakaya Y
Department Of Nutrition And Metabolism University Of Tokushima Graduate School
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Nakaya Yutaka
Department Of Nutrition School Of Medicine The University Of Tokushima
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Nakaya Yutaka
Department Of Nutrition And Metabolism Graduate School Of Nutrition And Bioscience The University Of
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Ito Susumu
徳島大学 大学院ヘルスバイオサイエンス研究部臓器病態治療医学
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Harada Kenji
Department Of Cardiology Tokushima Prefectural Central Hospital
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Nomura Masahiro
Department of Digestion and Cardiovascular Medicine, University of Tokushima
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Nishikado Akiyoshi
Department of Digestion and Cardiovascular Medicine, University of Tokushima
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Uehara Kouzoh
Department of Digestive and Cardiovascular Medicine, School of Medicine, University of Tokushima
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Harada K
Department Of Advanced Materials Science And Engineering Faculty Of Engineering Yamaguchi University
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Nakaya Y
Department Of Nutrition And Metabolism Institute Of Health Biosciences The University Of Tokushima G
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Ito Susumu
Department Of Digestive And Cardiolovascular Medicine Tokushima University Hospital
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Nomura M
Department Of Applied Chemistry Faculty Of Engineering Osaka University
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Nishikado A
Department Of Digestive And Cardiovascular Medicine University Of Tokushima Graduate School
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Ito S
Deparetment Of Internal Medicine (ii) Niigata University School Ofmedicine
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Nishikada Akiyoshi
Second Department Of Internal Medicine School Of Medicine. The University Of Tokushima
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Harada Kenji
Department Of Cardiology Chubu-rosai Hospital
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Harada Kenji
Department Of Applied Analysis And Complex Dynamical Systems Kyoto University
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Nishikado Akiyoshi
Second Department Of Internal Medicine School Of Medicine The University Of Tokushima
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Uehara K
Department Of Bioresources Chemistry Faculty Of Horticulture Chiba University
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